Molly Fitzgerald
Digital Marketing Communications – Wellmune® & GanedenBC30®
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Ganeden Probiotic GanedenBC30 Proves Successful In Minimizing Severity And Duration Of C. Diff

Mouse model study reinforces positive effects of probiotics for the immune system

CLEVELAND, OH (November 30, 2011) – Researchers from Ganeden, Inc. and Penn State College of Medicine have found that GanedenBC30, a probiotic (beneficial bacteria), has prolonged the survival of, and improved the stool consistency of, C. diff-induced colitis in mice. The study, "Bacillus Coagulams GBI-30 (BC30) improves indices of Clostridium difficile-induced colitis in mice" was published in the November issue of Gut Pathogens.

Clostridium difficile, often referred to as C. diff, is a bacterium that causes inflammation of the colon, known as colitis. People that have other illnesses or conditions requiring prolonged use of antibiotics, and the elderly, are at greater risk of acquiring C. diff.1 The disease sickens 500,000 people per year and causes 15,000-20,000 deaths annually.2 The cost to treat C. diff infections is $3.2 billion per year.3

The spectrum of C. diff-associated disease (CDAD) ranges from mild antibiotic associated diarrhea to severe (or even life threatening) colitis. CDAD is often treated successfully with standard antibiotics however, recurrence occurs in many patients.4

"Some previous clinical studies focused on combined treatment with vancomycin and probiotics," said Leo R. Fitzpatrick, PhD, lead principal investigator of the study and Associate Professor of Pharmacology at Penn State College of Medicine. "But in this study, administering only GanedenBC30 to C. diff-infected mice resulted in an improvement in the consistency of their stool and reduction in the severity of the disease. This information is particularly helpful and potentially applicable for individuals going into the hospital or a nursing home, where the likelihood of obtaining this disease is higher."

GanedenBC30 (Bacillus coagulans GBI-30 6086) is a patented natural probiotic manufactured by Ganeden that has been shown to support the immune and digestive systems.

While most strains of good bacteria need to be delivered in capsule form, Ganeden's probiotic delivery system is different—it can be consumed in a variety of foods and beverages such as muffins, yogurt, bars, and even tea. GanedenBC30 can also be found in more than 50 foods, including popular brands like Red Mango frozen yogurt and ice teas, Naked Pizza pizza dough, Heartland Sweeteners Nevella with Probiotics, and R.C. Bigelow's Herb Plus Tea.

"A second study that was recently completed reinforces the positive effects of GanedenBC30," said Dr. David Keller, Vice President of Scientific Operations of Ganeden. "This additional data, when it is made public, will further the understanding of how GanedenBC30 can be an important tool in dealing with C. diff."

The Centers For Disease Control (CDC) currently recommends that people who are hospitalized or on antibiotics follow these safety precautions to reduce the chance of acquiring C. diff or spreading to others: wash hands with soap and water, especially after using the restroom and before eating, and clean surfaces in bathrooms, kitchens, and other areas on a regular basis with household detergent/disinfectants.5

Ganeden helped design, fund, and analyze the data of this study.

About Ganeden:

Ganeden is at the forefront of probiotic research and product development with an extensive library of published studies and more than 100 patents for probiotic technologies in the food, beverage, animal health, sports nutrition and personal care ingredients markets. Ganeden is best known for GanedenBC30 (Bacillus coagulans GBI-30, 6086), its patented, FDA GRAS, non-GMO, highly stable probiotic ingredient.  Ganeden's newest ingredient, Bonicel, is the first science-backed, probiotic-derived, personal care ingredient shown to dramatically reduce signs of aging.  For more information about Ganeden and licensing opportunities visit
4 [8-11] Fitzpatrick et al: Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridum difficile-induced colitis in mice. Gut Pathogens 2011, 3:16.

Ganeden is a science focused organization dedicated to bringing superior probiotics to markets that have been otherwise unmet by traditional solutions.

All Ganeden ingredients are made in the United States of America.