Our Published Research


 Peer-Reviewed, Published Studies and Counting

As a science-based company, Ganeden engages in rigorous scientific research and testing of all of its ingredients to ensure the most stable, efficacious probiotic finished products available. Here you’ll find links to published probiotic clinical studies on GanedenBC30.

The Combined Effect of Bacillus Coagulans GBI-30, 6086 and HMB Supplementation on Muscle Integrity and Cytokine Response during Intense Military Training

Journal of Applied Physiology

Yftach Gepner, Jay R. Hoffman, Elad Shemesh, Jeffrey R. Stout, David D. Church, Alyssa N. Varanoske, Hila Zelicha, Ilan Shelef, Yacov Chen, Hagai Frankel, Ishay Ostfeld


The purpose of this study was to compare the co-administration of the probiotic Bacillus coagulans GBI-30, 6086 (BC30) with β-hydroxy-β-methylbutyrate (HMB) calcium (CaHMB) to CaHMB alone on the inflammatory response and muscle integrity during 40-days of intense military training. Soldiers were randomly assigned to one of two groups: CaHMB with BC30 (CaHMBBC30; n=9) or CaHMB with placebo (CaHMBPL, n=9). A third group of participants served as a control (CTL; n=8). During the first 28 days soldiers were garrisoned on base and participated in the same training tasks. During the final 2 weeks soldiers navigated 25-30 km per night in difficult terrain carrying ~35 kg of equipment. All assessments (blood draws and diffusion tensor imaging to assess muscle integrity) were conducted prior to and approximately 12 hours following final supplement consumption. Analysis of covariance was used to analyze all blood and muscle measures. Significant attenuations were noted in IL-1β, IL-2, IL-6, CX3CL1, and TNF-α for both CaHMBBC30 and CaHMBPL compared to CTL. Plasma IL-10 concentrations were significantly attenuated for CaHMBBC30 compared to CTL only. A significant decrease in apparent diffusion coefficients was also observed for CaHMBBC30 compared to CaHMBPL. Results provide further evidence that HMB supplementation may attenuate the inflammatory response to intense training, and that the combination of the probiotic BC30 with CaHMB may be more beneficial than CaHMB alone in maintaining muscle integrity during intense military training.

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Probiotic Bacillus coagulans GBI-30, 6086 reduces exercise-induced muscle damage and increases recovery

PeerJ, July 2016

Ralf Jäger, Kevin A. Shields, Ryan P. Lowery, Eduardo O. De Souza, Jeremy M. Partl, Chase Hollmer, Martin Purpura and Jacob M. Wilson


Probiotics have been reported to support healthy digestive and immune function, aid in protein absorption, and decrease inflammation. Further, a trend to increase vertical jump power has been observed following co-administration of protein and probiotics in resistance-trained subjects. However, to date the potential beneficial effect of probiotics on recovery from high intensity resistance exercise have yet to be explored. Therefore, this study examined the effect of co-administration of protein and probiotics on muscle damage, recovery and performance following a damaging exercise bout.

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Integrate genome-based assessment of safety for probiotic strains: Bacillus coagulans GBI-30, 6086 as a case study

Applied Microbiology and Biotechnology

Elisa Salvetti, Luigi Orrù, Vittorio Capozzi, Alessia Martina, Antonella Lamontanara, David Keller, Howard Cash, Giovanna E. Felis, Luigi Cattivelli, Sandra Torriani, Giuseppe Spano


Probiotics are microorganisms that confer beneficialeffects on the host; nevertheless, before being allowed for human consumption, their safety must be verified with accurate protocols. In the genomic era, such procedures should take into account the genomic-based approaches. This study aims at assessing the safety traits of Bacillus coagulans GBI-30, 6086 integrating the most updated genomics-based procedures and conventional phenotypic assays.

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Nutritional profile and cooking quality of a new functional pasta naturally enriched in phenolic acids, added with β-glucan and Bacillus coagulans GBI-30, 6086

Journal of Cereal Science, Volume 65, September 2015, Pages 260–266

Clara Fares, Valeria Menga, Alessia Martina, Nicoletta Pellegrini, Francesca Scazzina, Sandra Torriani


A new functional pasta using a durum wheat flour rich in polyphenols, with added barley β-glucan and Bacillus coagulans GBI-30, 6086 was developed.

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Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women

The Journal of Nutrition May 2015

Edna P Nyangale, Sean Farmer, Howard A Cash, David Keller, David Chernoff, and Glenn R Gibson


Daily consumption of BC30 by adults aged 65–80 y can increase beneficial groups of bacteria in the human gut and potentially increase production of anti-inflammatory cytokines. This study shows the potential benefits of a probiotic to improve dysbiosis via modulation of the microbiota in older persons.

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Draft Genome Sequence of Bacillus coagulans GBI-30, 6086, a Widely Used Spore-Forming Probiotic Strain

Genome Announcements, November/December 2014 Volume 2 Issue 6

Luigi Orrù, Elisa Salvetti, Luigi Cattivelli, Antonella Lamontanara, Vania Michelotti, Vittorio Capozzi, Giuseppe Spano, David Keller, Howard Cash, Alessia Martina, Sandra Torriani, Giovanna E. Felis


Bacillus coagulans GBI-30, 6086 is a safe strain, already available on the market, and characterized by certified beneficial effects.

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Ganeden is a science focused organization dedicated to bringing superior probiotics to markets that have been otherwise unmet by traditional solutions.

All Ganeden ingredients are made in the United States of America.