The Research


 Peer-Reviewed, Published Studies and Counting

We engage in rigorous scientific research and testing of all of its ingredients to ensure the most stable, efficacious probiotic finished products available. Here you’ll find links to published probiotic clinical studies on GanedenBC30.

Probiotic metabolites from Bacillus coagulans GanedenBC30 support maturation of antigen-presenting cells in vitro

World Journal of Gastroenterology, 2012, 18(16): 1875–1883

Kathleen F Benson, Kimberlee A Redman, Steve G Carter, David Keller, Sean Farmer, John R Endres and Gitte S Jensen


In multiple validated lab models, testing demonstrated that GanedenBC30, (both cells walls and supernatant) supports immune health. 

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Bacillus coagulans GBI-30 (BC30) improves indices of Clostridium difficile-induced colitis in mice

Gut Pathogens, 2011, 3:16

Leo R Fitzpatrick, Jeffrey S Small, Wallace H Greene, Kelly D Karpa and David Keller


A validated mouse model that GanedenBC30 supports digestive health by prolonging survival and decreasing time to normalized stools in mice with Clostridium difficile induced colitis. 

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Impact of GanedenBC30 (Bacillus coagulans GBI-30, 6086) on population dynamics of the human gut microbiota in a continuous culture fermentation system

International Journal of Probiotics and Prebiotics, 2011, 6 (1): 65-72

Harue Honda, Lesley Hoyles, Glenn R. Gibson, Sean Farmer, David Keller and Anne L. McCartney


A validated large intestinal model (ascending colon) that demonstrated that GanedenBC30 germinates and populates the colon. 

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One-year chronic oral toxicity with combined reproduction toxicity study of a novel probiotic, Bacillus coagulans, as a food ingredient

Food and Chemical Toxicology, 2011, 49: 1174-1182

J.R. Endres, I. Qureshi, T. Farber, J. Hauswirth, G. Hirka, I. Pasics, and A.G. Schauss


A one-year toxicology study (which included a one generation reproduction study) that at 93.6 billion CFU (colony forming units) of GanedenBC30 could be safely consumed per day. 

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Use of a continuous culture fermentation system to investigate the effect of GanedenBC30 (Bacillus coagulans GBI-30, 6086) supplementation on pathogen survival in the human gut microbiota

Anarobe 2011, 17 (1): 36-42

H. Honda, G.R. Gibson, S. Farmer, D. Keller, and A.L. McCartney


A validated large intestinal model that demonstrated GanedenBC30 germinates and populates the colon. 

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Bacillus coagulans as a probiotic

Food Science & Technology Bulletin: Functional Foods 2010, 7 (7): 103-109

D. Keller, S. Farmer, A.L. McCartney, and G. Gibson


A review paper on the basics of probiotics, and the overall science that supports GanedenBC30.

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Ganeden is a science focused organization dedicated to bringing superior probiotics to markets that have been otherwise unmet by traditional solutions.

All Ganeden ingredients are made in the United States of America.