The Research


 Peer-Reviewed, Published Studies and Counting

We engage in rigorous scientific research and testing of all of its ingredients to ensure the most stable, efficacious probiotic finished products available. Here you’ll find links to published probiotic clinical studies on GanedenBC30.

Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women

The Journal of Nutrition May 2015

Edna P Nyangale, Sean Farmer, Howard A Cash, David Keller, David Chernoff, and Glenn R Gibson


Daily consumption of BC30 by adults aged 65–80 y can increase beneficial groups of bacteria in the human gut and potentially increase production of anti-inflammatory cytokines. This study shows the potential benefits of a probiotic to improve dysbiosis via modulation of the microbiota in older persons.

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Draft Genome Sequence of Bacillus coagulans GBI-30, 6086, a Widely Used Spore-Forming Probiotic Strain

Genome Announcements, November/December 2014 Volume 2 Issue 6

Luigi Orrù, Elisa Salvetti, Luigi Cattivelli, Antonella Lamontanara, Vania Michelotti, Vittorio Capozzi, Giuseppe Spano, David Keller, Howard Cash, Alessia Martina, Sandra Torriani, Giovanna E. Felis


Bacillus coagulans GBI-30, 6086 is a safe strain, already available on the market, and characterized by certified beneficial effects.

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Effect of prebiotics on the fecal microbiota of elderly volunteers after dietary supplementation of Bacillus coagulans GBI-30, 6086

Anaerobe Volume 30, December 2014, Pages 75–81

Edna P. Nyangale, Sean Farmer, David Keller, David Chernoff, Glenn R. Gibson


In a validated large intestinal model, it was demonstrated that there is an increased effect when consuming prebiotics along with GanedenBC30 versus prebiotics alone. 

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Immunomodulation of Antiretroviral Drug-Suppressed Chronic HIV-1 Infection in an Oral Probiotic Double-Blind Placebo-Controlled Trial

AIDS Research and Human Retroviruses October 2014, 30(10): 988-995. doi:10.1089/aid.2014.0181.

Yang Otto O., Kelesidis Theodoros, Cordova Robert, and Khanlou Homayoon


A randomized double blind placebo controlled trial in HIV+ subjects that demonstrated both immune and GI benefits. In addition, no adverse effects were see even in this immune-compramised population. 

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Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-induced colitis following vancomycin withdrawal in mice

Gut Pathogens, 2012, 4:13

Leo R Fitzpatrick, Jeffrey S Small, Wallace H Greene, Kelly D Karpa, Sean Farmer and David Keller


A validated mouse model study that GanedenBC30 supports digestive health by decreasing the recurrence rate of Clostridium difficile induced colitis. 

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A review of probiotics studies in HIV research suggests improved immunological presentation and preservation of viral host restrictive factors of TH17 in HIV patients

Retrovirology, 2012, 9(Suppl 1):P22

M Selbovitz, Keller, Miller, Moore, Farmer and Bray


A review of select previous studies conducted with probiotics and HIV patients, and discussion on potential uses of GanedenBC30 in this population. 

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Ganeden is a science focused organization dedicated to bringing superior probiotics to markets that have been otherwise unmet by traditional solutions.

All Ganeden ingredients are made in the United States of America.