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Impact of GanedenBC30 (Bacillus coagulans GBI-30, 6086) on population dynamics of the human gut microbiota in a continuous culture fermentation system

International Journal of Probiotics and Prebiotics, 2011, 6 (1): 65-72

Harue Honda, Lesley Hoyles, Glenn R. Gibson, Sean Farmer, David Keller and Anne L. McCartney

Abstract

Interest in Bacillus probiotics, for use in humans and other animals, is increasing. GanedenBC30 (Bacillus coagulans GBI-30, 6086) is a commercially available probiotic that is considered safe for human use. Few data are available in relation to the impact of Bacillus coagulans supplementation on the gut microbiota of animals, with none available for humans. In vitro single-stage continuous culture fermentation experiments were performed to examine the effect of GanedenBC30 supplementation on the human gut microbiota and to determine persistence of the probiotic strain upon cessation of supplementation. Fluorescence in situ hybridization and denaturing gradient gel electrophoresis were employed to monitor bacterial populations within the fermentation systems, while cultivation work was performed to examine the aerobic spore-formers in samples. GanedenBC30 supplementation had no major effect on the microbiota in vitro, although post-treatment clustering was seen for DGGE profiles. Both cultivation and fluorescence in situ hybridization analysis (with probe Bcoa191) demonstrated persistence of GanedenBC30 in vitro post-treatment and indicated germination of spores in vitro. GanedenBC30 supplementation did not cause dybiosis of the human gut microbiota in vitro,  indicating GanedenBC30 is microbiologically safe for probiotic application in humans. Future work should examine the potential probiotic function(s) of GanedenBC30, including its immunomodulatory and antimicrobial effects. 

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